PoplarV1, Main, Exploration, bibRecord, 003224

Identification of hydroxylated metabolites of 3,3',4,4'-tetrachlorobiphenyl and metabolic pathway in whole poplar plants.

Identifieur interne : 003224 ( Main/Exploration ); précédent : 003223; suivant : 003225

Identification of hydroxylated metabolites of 3,3',4,4'-tetrachlorobiphenyl and metabolic pathway in whole poplar plants.

Auteurs : Guangshu Zhai [États-Unis] ; Hans-Joachim Lehmler ; Jerald L. Schnoor

Source :

Chemosphere [ 1879-1298 ] ; 2010.

RBID : pubmed:20708213

Descripteurs français

English descriptors

KwdEn :
- Chromatography, Liquid (MeSH), Environmental Monitoring (MeSH), Environmental Pollutants (chemistry), Environmental Pollutants (metabolism), Hydroxylation (MeSH), Metabolic Networks and Pathways (MeSH), Polychlorinated Biphenyls (chemistry), Polychlorinated Biphenyls (metabolism), Populus (chemistry), Populus (metabolism), Spectrometry, Mass, Electrospray Ionization (MeSH).
MESH :
- chemical , chemistry : Environmental Pollutants, Polychlorinated Biphenyls.
- chemical , metabolism : Environmental Pollutants, Polychlorinated Biphenyls.
- chemistry : Populus.
- metabolism : Populus.
- Chromatography, Liquid, Environmental Monitoring, Hydroxylation, Metabolic Networks and Pathways, Spectrometry, Mass, Electrospray Ionization.

Abstract

Polychlorinated biphenyls (PCBs) can be metabolized to hydroxylated polychlorinated biphenyls (OH-PCBs) as reported in a number of animal studies. However, there are few studies on OH-PCBs in vivo in whole plants. In order to explore the formation of OH-PCBs in whole plants in detail, poplars (Populus deltoides×nigra, DN34) were exposed to 3,3',4,4'-tetrachlorobiphenyl (CB77) in hydroponic solution. Poplars are widely used in phytoremediation applications and the complete genome has been sequenced. In this research, a HPLC-MS method was developed to directly determine the hydroxylated metabolites of CB77 (OH-CB77s), avoiding the experimental errors introduced by derivatization pretreatments required by gas chromatography-based methods. Three potential hydroxylated metabolites of CB77, including 6-hydroxy-3,3',4,4'-tetrachlorobiphenyl (6OH-CB77), 5-hydroxy-3,3',4,4'-tetrachlorobiphenyl (5OH-CB77) and 4'-hydroxy-3,3',4,5'-tetrachlorobiphenyl (4'OH-CB79), were determined in poplar tissues. The major product, 6OH-CB77, was detected in the roots, bottom bark, bottom wood, middle bark and middle wood for the whole poplar plants, but the minor product, 5OH-CB77, was detected only in the poplar roots. The concentration of 6OH-CB77 was about 10 times greater than that of 5OH-CB77 in the roots. However, the major mammalian metabolite, 4'OH-CB79 was not detected in any of the samples. The results suggest that the hydroxylated metabolic pathway of CB77 is via an epoxide intermediate in poplar.

DOI: 10.1016/j.chemosphere.2010.07.036
PubMed: 20708213
PubMed Central: PMC2943055

Affiliations:

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Polychlorinated biphenyls (PCBs) can be metabolized to hydroxylated polychlorinated biphenyls (OH-PCBs) as reported in a number of animal studies. However, there are few studies on OH-PCBs in vivo in whole plants. In order to explore the formation of OH-PCBs in whole plants in detail, poplars (Populus deltoides×nigra, DN34) were exposed to 3,3',4,4'-tetrachlorobiphenyl (CB77) in hydroponic solution. Poplars are widely used in phytoremediation applications and the complete genome has been sequenced. In this research, a HPLC-MS method was developed to directly determine the hydroxylated metabolites of CB77 (OH-CB77s), avoiding the experimental errors introduced by derivatization pretreatments required by gas chromatography-based methods. Three potential hydroxylated metabolites of CB77, including 6-hydroxy-3,3',4,4'-tetrachlorobiphenyl (6OH-CB77), 5-hydroxy-3,3',4,4'-tetrachlorobiphenyl (5OH-CB77) and 4'-hydroxy-3,3',4,5'-tetrachlorobiphenyl (4'OH-CB79), were determined in poplar tissues. The major product, 6OH-CB77, was detected in the roots, bottom bark, bottom wood, middle bark and middle wood for the whole poplar plants, but the minor product, 5OH-CB77, was detected only in the poplar roots. The concentration of 6OH-CB77 was about 10 times greater than that of 5OH-CB77 in the roots. However, the major mammalian metabolite, 4'OH-CB79 was not detected in any of the samples. The results suggest that the hydroxylated metabolic pathway of CB77 is via an epoxide intermediate in poplar.</div>
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<Abstract><AbstractText>Polychlorinated biphenyls (PCBs) can be metabolized to hydroxylated polychlorinated biphenyls (OH-PCBs) as reported in a number of animal studies. However, there are few studies on OH-PCBs in vivo in whole plants. In order to explore the formation of OH-PCBs in whole plants in detail, poplars (Populus deltoides×nigra, DN34) were exposed to 3,3',4,4'-tetrachlorobiphenyl (CB77) in hydroponic solution. Poplars are widely used in phytoremediation applications and the complete genome has been sequenced. In this research, a HPLC-MS method was developed to directly determine the hydroxylated metabolites of CB77 (OH-CB77s), avoiding the experimental errors introduced by derivatization pretreatments required by gas chromatography-based methods. Three potential hydroxylated metabolites of CB77, including 6-hydroxy-3,3',4,4'-tetrachlorobiphenyl (6OH-CB77), 5-hydroxy-3,3',4,4'-tetrachlorobiphenyl (5OH-CB77) and 4'-hydroxy-3,3',4,5'-tetrachlorobiphenyl (4'OH-CB79), were determined in poplar tissues. The major product, 6OH-CB77, was detected in the roots, bottom bark, bottom wood, middle bark and middle wood for the whole poplar plants, but the minor product, 5OH-CB77, was detected only in the poplar roots. The concentration of 6OH-CB77 was about 10 times greater than that of 5OH-CB77 in the roots. However, the major mammalian metabolite, 4'OH-CB79 was not detected in any of the samples. The results suggest that the hydroxylated metabolic pathway of CB77 is via an epoxide intermediate in poplar.</AbstractText>
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   |clé=     pubmed:20708213
   |texte=   Identification of hydroxylated metabolites of 3,3',4,4'-tetrachlorobiphenyl and metabolic pathway in whole poplar plants.
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Identification of hydroxylated metabolites of 3,3',4,4'-tetrachlorobiphenyl and metabolic pathway in whole poplar plants.

Identification of hydroxylated metabolites of 3,3',4,4'-tetrachlorobiphenyl and metabolic pathway in whole poplar plants.

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